Episode 41 – Dr.Ken Ford on AI, ketosis, evolution and better science
Show Notes Dr.Ford’s bio is impressive. He’s the Founder and Chief Executive Officer of the Florida Institute for Human & Machine Cognition (IHMC), a not-for-profit research institute providing a “new model for interdisciplinary research”. In addition to... a PhD in...
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Episode 40 – Epigenetics with Fabien Delahaye
Show Notes Fabien is @cuicuibyfabien on Twitter and works at The Center for Epigenomics at the Albert Einstein College of Medicine [1min5sec] Raphael asks Fabien to reveal who is behind the brilliant @EpgntxEinstein Twitter account rectifying falsehoods spread about...
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Episode 39 – Weikko Jaross tells us about mitochondria
Show Notes Weikko Jaross has a degree in Forest Engineering from the University of Washington and has an app called MitoCalc [3m12s] Raphael asks Weikko when he got interested in nutrition and why. [6m57s] Raphael asks Weikko if his initial experimentation with...
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Episode 38 – Fatty pancreas, Fatty liver and diabetes
Show Notes [2min40sec] Raphael asks Gabor what’s wrong with a fatty pancreas? Why do we care whether or not our pancreas is fatty? [6m41s] Gabor says pancreatic was thought to be particularly bad compared to other ectopic fat (e.g. intra-abdominal fat), which is one...
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Episode 37 – George Henderson takes us on a tour of public health research
Show Notes George Henderson is a research assistant in the Auckland University of Technology (AUT) George’s blog is https://hopefulgeranium.blogspot.fr/ and his Twitter handle is @puddleg [3min] Raphael asks George what he studies in the public health department...
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Episode 36 – Metabolic Syndrome Chapter 2: leptin
Show notes: George Henderson is a research assistant in the Auckland University of Technology (AUT) George’s blog is https://hopefulgeranium.blogspot.fr/ and his Twitter handle is @puddleg [3min] Raphael asks George what he studies in the public health department...
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Episode 35 – Luis Villasenor the founder of KetoGains
Show notes: Luis Villasenor’s website is https://ketogains.com/ and his Twitter handle is @KetoGains [2m15s] Raphael asks Luis what he was doing on Reddit a few years back and how it all started there? [4m10s] Raphael highlights the difference between a...
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Episode 34 – Metabolic Syndrome Chapter 1: insulin resistance
Sponsor: This podcast is sponsored by Health IQ, the fastest growing life insurance agency in the United States. To see if you qualify, get your free quote today at healthiq.com/BDN or mention the promo code BDN when you talk to a Health IQ...
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Episode 33 – Nick Mailer tightens nutrition’s loose philosophy screws
Show notes: Nick Mailer’s blog http://skimmed.cream.org/ and his Twitter @bokkiedog Check out Nick’s latest guest-post on hyperinsulinemia for https://baby.botherer.org called Sugar Sugar Baby, Get On Down The Line, Part 2 [3min] Raphael asks...
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Episode 32 – Dr.Feinman gives the 2017 Low-Carb State of the Union
Sponsor: This podcast is sponsored by Health IQ, the fastest growing life insurance agency in the United States. To see if you qualify, get your free quote today at healthiq.com/BDN or mention the promo code BDN when you talk to a Health IQ...
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Episode 31 – Richard Morris joins Gabor & Raphael for a nutrition nerd safari
Sponsor This podcast is sponsored by Health IQ, the fastest growing life insurance agency in the United States. To see if you qualify, get your free quote today at healthiq.com/BDN or mention the promo code BDN when you talk to a Health IQ...
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Episode 30 – Amy Berger on the Protein question
Show notes: Amy’s website is www.tuitnutrition.com and her Twitter is @TuitNutrition Check out her previous episode with us (#9) where we talked about her book The Alzheimer’s Antidote Amy just wrote a timely blog post on the theme of...
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Episode 29 – Steven Hamley zooms in & out on dietary patterns affecting our health
Show notes: Steven Hamley’s website http://www.stevenhamley.com.au/ and Twitter @stevenhamley I ask Steven why he started his blog and he explains that it all started when coming across the Paleo concept in 2010, sparking his interest in health...
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Episode 28 – Amber O’Hearn says meat heals & birds fly
Show notes: Amber’s guest post Ketogenic diet and Vitamin C: the 101 Amber’s website http://www.ketotic.org/ Amber’s Ketofest 2017 video presentation In her presentation Amber explains that that animal sourced foods (AFS) score high in terms...
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Episode 27 – Adipocytes and insulin resistance
Show notes: 60% of US adults are overweight to moderately obese but within that group there is great heterogeneity in their response to insulin ⇒ their degree of insulin sensitivity can vary more than sixfold at any given BMI within this...
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Episode 26 – Dr.Bikman: well behaved fat and good insulin signaling FTW
Discuss further on: https://ask.breaknutrition.com Show notes: Here’s Dr.Bikman’s Twitter profile The Bikman lab is in The College of Life Sciences of Brigham Young University It focuses on identifying first “the molecular mechanisms that...
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Episode 25 – Larry & Kay Lynne Diamond: education is power
Show notes: Larry started LCHF May 2013 lost 45kg (100lbs) Larry’s fat-loss and health journey on www.dietdoctor.com He’s @natureboyrr on Twitter Kay Lynne started LCHF lost 32kg (70lbs) Kay Lynne’s fat-loss and health journey on...
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Episode 24 – Tucker and Gabor on Seed Oils vs Refined Carbs – Part 2
Show notes: You can find Tucker Goodrich at http://yelling-stop.blogspot.com and on Twitter @tuckergoodrich Oxidative stress is the inevitable result of metabolism and basic chemistry, resulting from reactive oxygen species (ROS) like "slow"...
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Episode 23 – Tucker Goodrich dishes on bad fats
Show notes: Tucker’s blog is http://yelling-stop.blogspot.com and his Twitter is @tuckergoodrich Could avoiding seed oils be why Tucker, I and others have noticed the same anecdotal experience of increased resistance to sunburn? We discuss the...
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Episode 22 – Dietary (in)sanity with Dr.Ede
Show notes: Dr.Ede’s interesting professional background includes working as lab assistant in places like the Joslin Diabetes Center and the SUNY Stony Brook Department of Dermatology. She also became an M.D. at the University of Vermont...
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Episode 21 – measuring Acetyl-CoA in a live rat, for the sake of metabolism
Show notes: A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo (Perry and Shulman et al. 2017) Background Futile fat cycling “Regulation is easier if competing reactions are maintained in a cycling steady-state and then biased in one or...
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Episode 20 – Sweet, sweet insulin and you
Show notes: Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion (Kyriazis et al. 2012) Background Beta-cell metabolized nutrients (e.g. amino acids & glucose) stimulate...
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Episode 19 – Marty Kendall on nutrient dense diets
Show notes: Marty Kendall launched https://optimisingnutrition.com/ in 2015 and has 2 excellent Facebook groups called Optimising Nutrition and Marty Kendall’s Nutrient Optimiser Marty explains how his engineering background helps him make...
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Episode 18 – Peter Ballerstedt PhD: better nutrition through sustainable agriculture
Show notes: Peter gives his academic and professional background. Peter explains how his study of forage agronomy dove-tailed into his interest in nutrition after being faced with a diagnosis of diabetes. Peter defines ruminants. Peter explains...
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Episode 17 – Dr.Shawn Baker lifts like a crane and eats like a lion
Show notes: Amy Berger’s question “do you think the types of food we consume (and possibly even the amount) affect our nutrient requirements?” Comment 1: ”it seems like our requirements would be determined at least in part by the metabolic...
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Episode 16 – The curious case of Dr. Ted Naiman
[warning: choppy audio in certain sections, my apologies ] In this episode I ask Dr.Ted Naiman the following questions: How should doctors post patient results online and how not to do so? What’s the biggest misconception doctors have...
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Episode 15 – how do mTORC2 and ChREBP-β keep the fat cycle going?
Show notes: Study 1: “Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism” (2013 Tang et al.) This study looked at the activity of mTORC2 in the adipose tissue of miceFloxed-KO mice missing Rictor, a...
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Episode 14 – Freezing your fat off
Show notes: Study è “Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus” (Hanssen et al. 2015) Brown adipose tissue (BAT) was ‘rediscovered’ in 2009 Cold exposure increases BAT & its activity BAT...
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Episode 13 – What happens to fructose-fed monkeys?
Short summary: In episode 13 Gabor and I review a 2011 study looking at the metabolic consequences of rhesus monkeys being fed a grain-based diet supplemented with 500mL of fructose loaded Kool-Aid a day over a year. Show notes: The study:...
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Episode 12 – Decoding Cholesterol with Dave Feldman
Short summary: I talk to engineer Dave Feldman about what his dietary self-experiments taught him cholesterol in human physiology. His “N = 1” experimentation is not only very interesting and rigorous but most importantly, it cannot be...
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Episode 11 – Obesity: a bird’s eye view
Short summary: In episode 11 Gabor selects 2 papers on the physiology of migrating birds that fatten up for their voyage and we discuss what this can tell us about human obesity. The first paper is from 2002 by Bairlein and is called “How to...
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Episode 10 – Medical uses of ketogenic and low carb diets with Ellen Davis
Short summary: With guest Ellen Davis we discuss the many medical applications of ketogenic and low carb diets, all of which is explored in depth in her 3 books “Fighting Cancer with a Ketogenic Diet”, “The Ketogenic Diet for Type 1 Diabetes”...
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Episode 9 – Amy Berger’s new book “The Alzheimer’s Antidote”, gluconeogenesis and exogenous ketones
Short summary: In her new book “The Alzheimer’s Antidote”, Amy Berger explains how improving one’s metabolism through a well-formulated low-carb high-fat diet is a worthwhile strategy to manage the disease. We then discuss how ‘excess protein’...
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Episode 8 – starch digestibility and limitations of the glycemic response
In episode 8 of the Break Nutrition show we discuss 2 papers which explore the glycemic, insulin and incretin responses and how the digestibility of starch as well as the apportioning of endogenous vs exogenous glucose comes into play. The...
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Episode 7 – How processed starches affect metabolic responses
The first paper discussed is from 1989 and is called “Insulin and glycemic responses in healthy humans to native starches processed in different ways: correlation with in vitro alpha-amylase hydrolysis”...
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Episode 6 – why bariatric surgery improves metabolic parameters quickly
Episode 5 of the Break Nutrition Show Gabor and I had a discussion about the paper called "Mechanisms facilitating weight loss and resolution of type 2 diabetes following bariatric surgery". Mechanisms facilitating weight loss and resolution...
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Episode 5 – how enlarged adipocytes overloaded with lipids lead to insulin resistance
Episode 5 of the Break Nutrition Show Gabor and I had a discussion about the paper called “Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation”, covering the following points (and more):...
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Episode 4 – the rate at which sugar is absorbed by the gastro intestinal system affects obesity, diabetes and metabolic health
In episode 4 we discuss why the rate at which you absorb sugar may affect obesity, diabetes and general metabolic health, here is the 2 papers discussed: Effects of small intestinal glucose on glycaemia, insulinaemia and incretin hormone...
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Episode 3 – Affecting fat loss in rodents by caloric restriction, knocking out insulin genes and seeing how incretin hormones play into it
In Episode 3 of the Break Nutrition show we discussed rodent studies showing an insulin gene dosage-dependent effect on adiposity, the interplay between caloric restriction & circulating insulin, as well as how incretin hormones affect fat loss...
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Episode 2 – trafficking fatty acids properly to avoid ectopic fat deposition
In Episode 2 of the BreakNutrition Show we talked about how dysregulated cycling of fat between fat cells, the liver and the fat we eat can lead to obesity, here is the paper: Downregulation of adipose tissue fatty acid trafficking in obesity:...
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Episode 1 – Linking dysregulated adipocyte fat flow to diabetes
In Episode 1 of the BreakNutrition Show we talked about how how dysregulated fat flow from fat cells can drive the creation of new glucose in the liver and lead to diabetes, here is the paper: Hepatic acetyl CoA links adipose tissue...
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