Episode 39 - Weikko Jaross tells us about mitochondria
[3m12s] Raphael asks Weikko when he got interested in nutrition and why.
[6m57s] Raphael asks Weikko if his initial experimentation with ergogenic aids was to optimize his rowing.
[7m16s] Raphael asks Weikko if he had any performance doubts about the efficacy of his high-carb diet when rowing in college.
[8m57] Raphael asks Weikko what materials or people were influential in his learning about nutrition.
[13m36] Raphael asks Weikko why he was eating only 1,600 kcals/day when he weighed close to 85 kg !? And how did he do it?
[16m35s] Raphael asks Weikko how his food elimination protocols due to seasonal allergies led him to the ketogenic diet.
[21m6s] Raphael asks Weikko if he’s confident he could pop a folic acid pill and a placebo one and tell them apart.
[23min] Raphael asks Weikko to explain what he does with MitoKinetics and what the MitoCalc app is all about.
[27m50s] Raphael asks Weikko if he thinks there’s a ~300 kcal difference in energy balance between people on isocalorically matched ketogenic and low-fat diets. The claim being that keto provides a more negative energy balance during weight/fat-loss. Correction: the figure Raphael should have mentioned is 182.6±66 kcal/d from doubly labeled water (DLW) measures (Kevin Hall et al. 2015).
[31m10s] Raphael asks Weikko how carb-loading and ketosis affect the RQ (respiratory quotient).
[32m10s] Raphael asks Weikko what to clarify what the ketogenic diet informs MitoCalc’s Food quotient (FQ) measure that can estimate the RQ.
[33m30s] Raphael talks about Peter of Hyperlipid’s blog post where the case of a breast-feeding Eskimo woman with an RQ well below 0.7 at 0.454 is discussed. Raphael asks Weikko for his comment on this.
[37m10s] Raphael asks Weikko how can one be on a high-carb diet without having an RQ close to 1? In other words, how can one eat like a Kenyan marathoner yet be a ‘fat burning beast’?
[40m56s] Raphael asks Weikko if he expects his FQ measure will be used to assess one’s degree of metabolic flexibility (or proximity to the diabetic end of the spectrum).
[43m17s] Raphael explains how accurate our biological homeostat is in keeping some of us weight-stable for over 20-years, and how ‘tracking apps’ are nowhere close to be able to do that. So Weikko explains why MitoCalc can help even if it can’t track calories anywhere close to human level accuracy.
[45m53s] Raphael talks about the difference between giving ‘subtractive’ advice vs ‘additive’ advice, and how the latter happens to be more marketing-friendly and more in line with consumerism incentives.
[47m38s] Raphael asks Weikko what kind of person will want to use MitoCalc. What’s the audience?
[50m50s] Raphael asks Weikko when the MitoCalc app will be released. In the next few weeks!