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Episode 12 - Decoding Cholesterol with Dave Feldman

by Break Nutrition | Podcast

Short summary: I talk to engineer Dave Feldman about what his dietary self-experiments taught him cholesterol in human physiology. His “N = 1” experimentation is not only very interesting and rigorous but most importantly, it cannot be explained by current mainstream notions in lipidology. We also discuss the implications that this may have for cardiovascular disease.

Show notes:

  • Dave Feldman is known as the Christian Bale of nutrition for his extreme self-experiments where he ate 5,000 kcals per day, or fasted, ran half-marathons and did all of this see how his health and cholesterol responded – all in the name of science!
  • Dave gives his cholesterol elevator-pitch
  • Peter Attia says that “If you want to stop atherosclerosis, you must lower the LDL particle number. Period”. Dave doesn’t quite see it that way currently.
  • The Friedwald formula – not a direct measure of LDLc but an inference – can both underestimate LDLc if the TG/Cholesterol is > 5 and overestimate it if the ratio is < 5.
  • Dave observed that the “tightest [negative] correlation appeared with total fat in my diet and LDL-C cholesterol”. A 3-day timeframe had the tightest correlation of r2 = – 0.905.
  • Dave observed his small LDL-p correlate with total fat quite strongly (r2 = – 0.718).
  • Dave’s recent fasting experiment was cut short and small LDLp crashed ! Some would say this is counter intuitive.
  • Dave asked people on Twitter to predict his next LDLc value to demonstrate reasonable accurate predictions could be made. Here was my guess! (I was 18 mg/dL off)
  • Twitter questions

 

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