Episode 29 – Steven Hamley zooms in & out on dietary patterns affecting our health

Show notes: Steven Hamley’s website http://www.stevenhamley.com.au/ and Twitter @stevenhamley I ask Steven why he started his blog and he explains that it all started when coming across the Paleo concept in 2010, sparking his interest in health and disease given the utility of this framework compared to traditional modes of viewing these matters. We talk about the following points mentioned in the AHA’s 2017 Presidential Advisory paper “In summary, randomized controlled trials that lowered intake of dietary saturated fat and

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Episode 28 – Amber O’Hearn says meat heals & birds fly

  Show notes: Amber’s guest post Ketogenic diet and Vitamin C: the 101 Amber’s website http://www.ketotic.org/ Amber’s Ketofest 2017 video presentation In her presentation Amber explains that that animal sourced foods (AFS) score high in terms of diet quality, defined as the addition of 3 differently weighted parameters in the following formula ⇒ structural plant parts (e.g. indigestible cellulose) [weighting x2] Plant reproductive parts (e.g. starchy bulbs) [weighting x3.5] Animal prey (e.g. red meat) “[…] If our teeth aren’t well

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Episode 27 – Adipocytes and insulin resistance

Show notes:   60% of US adults are overweight to moderately obese but within that group there is great heterogeneity in their response to insulin ⇒ their degree of insulin sensitivity can vary more than sixfold at any given BMI within this range Adults constantly form and replace adipose cells, called turnover 2 places to measure fat are the femoral (leg fat) and subcutaneous (under your skin and predominantly white) adipose tissues For IMGU (insulin mediated glucose uptake), the higher

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Episode 26 – Dr.Bikman: well behaved fat and good insulin signaling FTW

Discuss further on: https://ask.breaknutrition.com Show notes: Here’s Dr.Bikman’s Twitter profile The Bikman lab is in The College of Life Sciences of Brigham Young University It focuses on identifying first “the molecular mechanisms that explain the increased risk of disease that accompanies weight gain, with particular emphasis on the etiology of insulin resistance and disrupted mitochondrial function. Second, we hope to reveal novel cellular processes that are responsible for fat development” Dr.Bikman enumerates some of the metabolic drugs used in disease

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Episode 25 – Larry & Kay Lynne Diamond: education is power

Show notes: Larry started LCHF May 2013 lost 45kg (100lbs) Larry’s fat-loss and health journey on www.dietdoctor.com He’s @natureboyrr on Twitter Kay Lynne started LCHF lost 32kg (70lbs) Kay Lynne’s fat-loss and health journey on www.marksdailyapple.com I ask Larry and Kay Lynne about how to best teach kids about food and health Kay Lynne explains the social challenge inherent for her daughter given she eats healthily (meat, vegetables, tubers and fruit) instead of the junk-food her classmates eat, but that

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Episode 24 – Tucker and Gabor on Seed Oils vs Refined Carbs – Part 2

Show notes: You can find Tucker Goodrich at http://yelling-stop.blogspot.com and on Twitter @tuckergoodrich Oxidative stress is the inevitable result of metabolism and basic chemistry, resulting from reactive oxygen species (ROS) like “slow” reacting hydrogen peroxide and “fast” reacting peroxyl radicals. Omega-6 and omega-3 PUFAs form peroxidation products like malondialdehyde, 4-hydroxynonenal (HNE) , isoprostanes or 9- and 13-hydroxyoctadecadienoic acids. Here’s a study from 2015 for more on PUFA chemistry.  PUFAs are not stable at the physiological temperature of ~37°C. When anti-oxidant action is lacking

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Episode 23 – Tucker Goodrich dishes on bad fats

Show notes: Tucker’s blog is http://yelling-stop.blogspot.com and his Twitter is @tuckergoodrich Could avoiding seed oils be why Tucker, I and others have noticed the same anecdotal experience of increased resistance to sunburn? We discuss the apportioning of seed oils, refined flours and sugars to diseases of civilization (2004) Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA “In summary, chronic caloric excess of n-6 PUFA when coupled with acute diabetes of only 4 days precipitated mitochondrial

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Episode 22 – Dietary (in)sanity with Dr.Ede

Show notes: Dr.Ede’s interesting professional background includes working as lab assistant in places like the Joslin Diabetes Center and the SUNY Stony Brook Department of Dermatology. She also became an M.D. at the University of Vermont College of Medicine and completed her residency in adult psychiatry at Harvard. In 2012 she completed a graduate course in nutrition from the Harvard School of Public Health entitled “The Science of Human Nutrition”. She is now the psychiatrist for Smith College (Northampton, Massachusetts)

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Episode 21 – measuring Acetyl-CoA in a live rat, for the sake of metabolism

Show notes: A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo (Perry and Shulman et al. 2017) Background Futile fat cycling “Regulation is easier if competing reactions are maintained in a cycling steady-state and then biased in one or another direction. This becomes, in the end, more efficient  than starts and stops in response to different conditions” Acetyl-CoA contributes to GNG, glucose oxidation, protein acetylation and the synthesis of steroids as well as fatty acids Episode 1 Break Nutrition study

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Episode 20 – Sweet, sweet insulin and you

Show notes: Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion (Kyriazis et al. 2012) Background Beta-cell metabolized nutrients (e.g. amino acids & glucose) stimulate insulin secretion whilst GLP-1 interacts with the beta-cell’s cell-surface GPCRs to stimulate insulin secretion [G-protein coupled receptor] There are many more Non-metabolizable insulin secretagogues than Metabolizable ones TRPM5 (Transient receptor potential cation channel subfamily M member 5) is found on surface of beta-cells, transducing taste for bitter, sweet, umami &

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