Episode 36 – Metabolic Syndrome Chapter 2: leptin

Show notes: [2m30s] Raphael explains that leptin and insulin have a lot of mechanistic overlap in terms of managing fat storage and energy distribution, making them crucial players in metabolic syndrome. [3m20s] Gabor explains that he lost interest in leptin a few back after concluding that it all seemed to happen downstream of insulin (further away from foundational cause(s)). [4m30s] Gabor talks about a study describing how leptin regulates the glucose-fatty acid cycle (see Lower Insulin Facebook group discussion of

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Episode 34 – Metabolic Syndrome Chapter 1: insulin resistance

Sponsor: This podcast is sponsored by Health IQ, the fastest growing life insurance agency in the United States. To see if you qualify, get your free quote today at healthiq.com/BDN or mention the promo code BDN when you talk to a Health IQ agent. [3min] Gabor gives the classical definition of insulin resistance (IR) that focuses on glucose disposal and explains its limited because it ignores other metabolic parameters, such as lipids. [4m45s] Raphael explains that the gold-standard method to

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Episode 27 – Adipocytes and insulin resistance

Show notes:   60% of US adults are overweight to moderately obese but within that group there is great heterogeneity in their response to insulin ⇒ their degree of insulin sensitivity can vary more than sixfold at any given BMI within this range Adults constantly form and replace adipose cells, called turnover 2 places to measure fat are the femoral (leg fat) and subcutaneous (under your skin and predominantly white) adipose tissues For IMGU (insulin mediated glucose uptake), the higher

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Episode 26 – Dr.Bikman: well behaved fat and good insulin signaling FTW

Discuss further on: https://ask.breaknutrition.com Show notes: Here’s Dr.Bikman’s Twitter profile The Bikman lab is in The College of Life Sciences of Brigham Young University It focuses on identifying first “the molecular mechanisms that explain the increased risk of disease that accompanies weight gain, with particular emphasis on the etiology of insulin resistance and disrupted mitochondrial function. Second, we hope to reveal novel cellular processes that are responsible for fat development” Dr.Bikman enumerates some of the metabolic drugs used in disease

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What is gluconeogenesis? How does does it control blood sugars?

Introduction: our very own sugar factory Step into the low-carb world and soon enough you’ll hear the term GlucoNeoGenesis. GNG for short, is your body’s ability to construct glucose, a kind of sugar, out of molecules that aren’t glucose. It does this to ensure that, if you don’t eat any carbs, the cells in your body that need glucose will still get enough of it. It’s one reason why humans are so good at fasting or delaying death from starvation

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Episode 8 – starch digestibility and limitations of the glycemic response

In episode 8 of the Break Nutrition show we discuss 2 papers which explore the glycemic, insulin and incretin responses and how the digestibility of starch as well as the apportioning of endogenous vs exogenous glucose comes into play. The paper from 2012 is “Slowly and rapidly digestible starchy foods can elicit a similar glycemic response because of differential tissue glucose uptake in healthy men” http://www.ncbi.nlm.nih.gov/pubmed/22990033. The paper from 2015 is “Plasma glucose kinetics and response of insulin and GIP

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Episode 5 – how enlarged adipocytes overloaded with lipids lead to insulin resistance

 Episode 5 of the Break Nutrition Show Gabor and I  had a discussion about the paper called “Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation”, covering the following points (and more): Link: http://www.ncbi.nlm.nih.gov/pubmed/25733684 The concept of IR occurring after the lipid-derived enlargement of adipocytes (as opposed to the other model of IR preceding it) The difference in mild/early-stage obesity versus severe/late-stage obesity Mechanisms whereby adipocyte-focused inflammation appears necessary to make adipocytes more insulin resistance in severe/late-stage obesity but not in

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Episode 4 – the rate at which sugar is absorbed by the gastro intestinal system affects obesity, diabetes and metabolic health

In episode 4 we discuss why the rate at which you absorb sugar may affect obesity, diabetes and general metabolic health, here is the 2 papers discussed: Effects of small intestinal glucose on glycaemia, insulinaemia and incretin hormone release are load-dependent in obese subjects Link: http://www.ncbi.nlm.nih.gov/pubmed/27840416 Accelerated intestinal glucose absorption in morbidly obese humans: relationship to glucose transporters, incretin hormones, and glycemia Link: http://www.ncbi.nlm.nih.gov/pubmed/25423571

Episode 3 – Affecting fat loss in rodents by caloric restriction, knocking out insulin genes and seeing how incretin hormones play into it

In Episode 3 of the Break Nutrition show we discussed rodent studies showing an insulin gene dosage-dependent effect on adiposity, the interplay between caloric restriction & circulating insulin, as well as how incretin hormones affect fat loss dynamics. Caloric Restriction Paradoxically Increases Adiposity in Mice With Genetically Reduced Insulin. Link: https://www.ncbi.nlm.nih.gov/m/pubmed/27145011/ Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity. Link: https://www.ncbi.nlm.nih.gov/m/pubmed/26155745/?i=3&from=/27145011/related