Episode 19 – Marty Kendall on nutrient dense diets

Show notes: Marty Kendall launched https://optimisingnutrition.com/ in 2015 and has 2 excellent Facebook groups called Optimising Nutrition and Marty Kendall’s Nutrient Optimiser Marty explains how his engineering background helps him make sense of nutrition science What’s the nutrient optimizer? Marty explains his 3-pronged approach for recommending foods based on their insulin index, nutrient density and energy density We discuss the fact that RDIs (recommended daily intake of nutrients) were established in omnivorous diets (relatively) high in carbohydrates and how this

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Episode 18 – Peter Ballerstedt PhD: better nutrition through sustainable agriculture

Show notes: Peter gives his academic and professional background. Peter explains how his study of forage agronomy dove-tailed into his interest in nutrition after being faced with a diagnosis of diabetes. Peter defines ruminants. Peter explains how ruminants can reverse desertification, rendering land productive that otherwise cannot grow crops. Peter discusses the ratio of omega-6-to-omega-3 fats in our foods and how different food for cows affect the ratio in their meat Peter explains how absolute quantities of these fats might

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Episode 17 – Dr.Shawn Baker lifts like a crane and eats like a lion

Show notes: Amy Berger’s question “do you think the types of food we consume (and possibly even the amount) affect our nutrient requirements?” Comment 1: ”it seems like our requirements would be determined at least in part by the metabolic processes we have going on, and an all-meat diet might depend on particular processes more or less than an omnivorous low-carb diet, or a vegan diet, high-carb, or any other approach” Comment 2: “it seems like whatever was taken into

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Episode 16 – The curious case of Dr. Ted Naiman

[warning: choppy audio in certain sections, my apologies ] In this episode I ask Dr.Ted Naiman the following questions:   How should doctors post patient results online and how not to do so? What’s the biggest misconception doctors have regarding diabetes? What’s the biggest misconception patients have regarding fat-loss? Dr.Naiman makes wonderful memes to explain concepts about health and nutrition. What’s a Protein-Sparing Modified Fast (PSMF)? Dr.Eric Westman places a lot of emphasis on carbohydrate restriction and very little on

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Episode 15 – how do mTORC2 and ChREBP-β keep the fat cycle going?

Show notes: Study 1: “Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism” (2013 Tang et al.) This study looked at the activity of mTORC2 in the adipose tissue of miceFloxed-KO mice missing Rictor, a key element in the mTORC2 complex, were used in this study In the liver, de novo lipogenesis (DNL) correlates with insulin resistance (IR) but in white adipose tissue (WAT) it correlated with insulin sensitivity (IS) The activity of Carbohydrate-response Element Binding Protein

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Episode 14 – Freezing your fat off

Show notes: Study è “Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus” (Hanssen et al. 2015) Brown adipose tissue (BAT) was ‘rediscovered’ in 2009 Cold exposure increases BAT & its activity BAT activity was determined by measured glucose uptake via 18FDG PET-CT Data suggests BAT activation correlates with decreased triglycerides in BAT tissue More glucose was taken up (on average) in skeletal muscle & BAT tissue post-cold adaptation Uncoupling potein-1 (UCP-1) expressing white adipose tissue

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Episode 13 – What happens to fructose-fed monkeys?

Short summary: In episode 13 Gabor and I review a 2011 study looking at the metabolic consequences of rhesus monkeys being fed a grain-based diet supplemented with 500mL of fructose loaded Kool-Aid a day over a year. Show notes: The study: Fructose-Fed Rhesus Monkeys: A Nonhuman Primate Model of Insulin Resistance, Metabolic Syndrome, and Type 2 Diabetes (Bremer et al. 2001) Gabor explains what is fructose, glucose and high-fructose corn syrup (HFCS) Gabor explains the enzymatic means by which HFCS

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Episode 12 – Decoding Cholesterol with Dave Feldman

Short summary: I talk to engineer Dave Feldman about what his dietary self-experiments taught him cholesterol in human physiology. His “N = 1” experimentation is not only very interesting and rigorous but most importantly, it cannot be explained by current mainstream notions in lipidology. We also discuss the implications that this may have for cardiovascular disease. Show notes: Dave Feldman is known as the Christian Bale of nutrition for his extreme self-experiments where he ate 5,000 kcals per day, or

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Episode 11 – Obesity: a bird’s eye view

Short summary: In episode 11 Gabor selects 2 papers on the physiology of migrating birds that fatten up for their voyage and we discuss what this can tell us about human obesity. The first paper is from 2002 by Bairlein and is called “How to get fat: nutritional mechanisms of seasonal fat accumulation in migratory songbirds” http://www.ncbi.nlm.nih.gov/pubmed/12008967. The second is called “Adipose energy stores, physical work, and the metabolic syndrome: lessons from hummingbirds” http://www.ncbi.nlm.nih.gov/pubmed/16351726 and is by Hargrove et al.

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Episode 10 – Medical uses of ketogenic and low carb diets with Ellen Davis

Short summary: With guest Ellen Davis we discuss the many medical applications of ketogenic and low carb diets, all of which is explored in depth in her 3 books “Fighting Cancer with a Ketogenic Diet”, “The Ketogenic Diet for Type 1 Diabetes” and “Conquering Type 2 Diabetes with a Ketogenic Diet”. Show notes: • Ellen’s books “Fighting Cancer with a Ketogenic Diet”, “The Ketogenic Diet for Type 1 Diabetes” and “Conquering Type 2 Diabetes with a Ketogenic Diet” • Who

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