Episode 36 – Metabolic Syndrome Chapter 2: leptin

Show notes: [2m30s] Raphael explains that leptin and insulin have a lot of mechanistic overlap in terms of managing fat storage and energy distribution, making them crucial players in metabolic syndrome. [3m20s] Gabor explains that he lost interest in leptin a few back after concluding that it all seemed to happen downstream of insulin (further away from foundational cause(s)). [4m30s] Gabor talks about a study describing how leptin regulates the glucose-fatty acid cycle (see Lower Insulin Facebook group discussion of

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Episode 35 – Luis Villasenor the founder of KetoGains

Show notes: Luis Villasenor’s website is https://ketogains.com/ and his Twitter handle is @KetoGains [2m15s] Raphael asks Luis what he was doing on Reddit a few years back and how it all started there? [4m10s] Raphael highlights the difference between a classical ketogenic diet conceived in the last century and a more modern, mainstream and well-formulated ketogenic diet eschewing refined flours, seed oils and other junk food. [6m50s] Luis explains that Ketogains gives more importance to body recomposition (body fat %

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Episode 34 – Metabolic Syndrome Chapter 1: insulin resistance

Sponsor: This podcast is sponsored by Health IQ, the fastest growing life insurance agency in the United States. To see if you qualify, get your free quote today at healthiq.com/BDN or mention the promo code BDN when you talk to a Health IQ agent. [3min] Gabor gives the classical definition of insulin resistance (IR) that focuses on glucose disposal and explains its limited because it ignores other metabolic parameters, such as lipids. [4m45s] Raphael explains that the gold-standard method to

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Episode 33 – Nick Mailer tightens nutrition’s loose philosophy screws

Show notes: Nick Mailer’s blog http://skimmed.cream.org/ and his Twitter @bokkiedog Check out Nick’s latest guest-post on hyperinsulinemia for https://baby.botherer.org called Sugar Sugar Baby, Get On Down The Line, Part 2 [3min] Raphael asks Nick where his interest in nutrition comes from and why he ‘cares’ to call out bad science. Nick explains that his radical skepticism is largely to blame as well as his own self-awareness regarding his behavior around food. [17m15s] Raphael asks Nick if he knows the Very Bad

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Episode 32 – Dr.Feinman gives the 2017 Low-Carb State of the Union

Sponsor: This podcast is sponsored by Health IQ, the fastest growing life insurance agency in the United States. To see if you qualify, get your free quote today at healthiq.com/BDN or mention the promo code BDN when you talk to a Health IQ agent. Show notes: Professor Feinman’s blog https://feinmantheother.com/, Twitter @DrFeinman and book The World Turned Upside Down [4m20s]Raphael asks Dr.Feinman what the Nutrition and Metabolism Society is all about [6m20] Prof Feinman and Raphael agree that getting original,

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Episode 31 – Richard Morris joins Gabor & Raphael for a nutrition nerd safari

Sponsor This podcast is sponsored by Health IQ, the fastest growing life insurance agency in the United States. To see if you qualify, get your free quote today at healthiq.com/BDN or mention the promo code BDN when you talk to a Health IQ agent.   Show notes: Richard’s website is http://2ketodudes.com/ and Twitter is @2ketodudes Richard gives his professional background; after half a maths degree he changed direction to a successful career on Wall Street and as a computer coder,

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Episode 30 – Amy Berger on the Protein question

Show notes: Amy’s website is www.tuitnutrition.com and her Twitter is @TuitNutrition Check out her previous episode with us (#9) where we talked about her book The Alzheimer’s Antidote Amy just wrote a timely blog post on the theme of information overload, which leads to paralysis by analysis and can be solved by….an information vacation! The world of nutrition is divided over Carbohydrates vs Fats while protein historically assumes a rather unifying role Nevertheless, there’s controversy about How much protein is

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Episode 29 – Steven Hamley zooms in & out on dietary patterns affecting our health

Show notes: Steven Hamley’s website http://www.stevenhamley.com.au/ and Twitter @stevenhamley I ask Steven why he started his blog and he explains that it all started when coming across the Paleo concept in 2010, sparking his interest in health and disease given the utility of this framework compared to traditional modes of viewing these matters. We talk about the following points mentioned in the AHA’s 2017 Presidential Advisory paper “In summary, randomized controlled trials that lowered intake of dietary saturated fat and

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Episode 28 – Amber O’Hearn says meat heals & birds fly

  Show notes: Amber’s guest post Ketogenic diet and Vitamin C: the 101 Amber’s website http://www.ketotic.org/ Amber’s Ketofest 2017 video presentation In her presentation Amber explains that that animal sourced foods (AFS) score high in terms of diet quality, defined as the addition of 3 differently weighted parameters in the following formula ⇒ structural plant parts (e.g. indigestible cellulose) [weighting x2] Plant reproductive parts (e.g. starchy bulbs) [weighting x3.5] Animal prey (e.g. red meat) “[…] If our teeth aren’t well

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Episode 27 – Adipocytes and insulin resistance

Show notes:   60% of US adults are overweight to moderately obese but within that group there is great heterogeneity in their response to insulin ⇒ their degree of insulin sensitivity can vary more than sixfold at any given BMI within this range Adults constantly form and replace adipose cells, called turnover 2 places to measure fat are the femoral (leg fat) and subcutaneous (under your skin and predominantly white) adipose tissues For IMGU (insulin mediated glucose uptake), the higher

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