Blog Posts

Episode 17 – Dr.Shawn Baker lifts like a crane and eats like a lion

Show notes: Amy Berger’s question “do you think the types of food we consume (and possibly even the amount) affect our nutrient requirements?” Comment 1: ”it seems like our requirements would be determined at least in part by the metabolic processes we have going on, and an all-meat diet might depend on particular processes more or less than an omnivorous low-carb diet, or a vegan diet, high-carb, or any other approach” Comment 2: “it seems like whatever was taken into

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Does beta hydroxybutyrate have an evil twin?

beta hydroxybutyrate

The discovery of CH3CH(OH)CH2CO2H CH3CH(OH)CH2CO2H = beta hydroxybutyrate. It’s a molecule your body makes from fats. The correct spelling is β-hydroxybutyrate or 3-hydroxybutyrate and is often abbreviated BHB. We’ll use beta hydroxybutyrate here. It all started in 1887. Well, actually 22 years earlier in 1865 when scientists discovered a molecule called acetoacetate in the pee of diabetic patients. Acetoacetate is a ketone or also known as a ketone body. Discovering acetoacetate eventually led them to discover beta hydroxybutyrate. Beta hydroxybutyrate was

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Episode 16 – The curious case of Dr. Ted Naiman

[warning: choppy audio in certain sections, my apologies ] In this episode I ask Dr.Ted Naiman the following questions:   How should doctors post patient results online and how not to do so? What’s the biggest misconception doctors have regarding diabetes? What’s the biggest misconception patients have regarding fat-loss? Dr.Naiman makes wonderful memes to explain concepts about health and nutrition. What’s a Protein-Sparing Modified Fast (PSMF)? Dr.Eric Westman places a lot of emphasis on carbohydrate restriction and very little on

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Can people with epilepsy benefit from the ketogenic diet?

What is the ketogenic diet? Some might consider the ketogenic diet to be a fad diet, however, it was discovered centuries ago for the dietary management of refractory epilepsy. The ketogenic diet is a high fat, adequate protein and low carbohydrate diet.   The diet was discovered by the observation of decreased seizure frequency during episodes of fasting.  In 1921, Dr. Wilder at Mayo clinic suggested the ketogenic diet for the long-term management of epilepsy. In terms of this suggestion, it

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Episode 15 – how do mTORC2 and ChREBP-β keep the fat cycle going?

Show notes: Study 1: “Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism” (2013 Tang et al.) This study looked at the activity of mTORC2 in the adipose tissue of miceFloxed-KO mice missing Rictor, a key element in the mTORC2 complex, were used in this study In the liver, de novo lipogenesis (DNL) correlates with insulin resistance (IR) but in white adipose tissue (WAT) it correlated with insulin sensitivity (IS) The activity of Carbohydrate-response Element Binding Protein

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Cold thermogenesis: how to freeze your fat off


Technology as a crutch The industrial age started in the late 18th century in the United Kingdom and with it, brought about technologies that now keep us in the Goldilocks zone, not too hot not too cold. In effect, we outsourced a fundamental aspect of what it means to stay alive and well temperature control Specifically, we now do very little cold thermogenesis. It’s a process mammals like us use to produce heat in order to stay warm. Our bodies

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Episode 14 – Freezing your fat off

Show notes: Study è “Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus” (Hanssen et al. 2015) Brown adipose tissue (BAT) was ‘rediscovered’ in 2009 Cold exposure increases BAT & its activity BAT activity was determined by measured glucose uptake via 18FDG PET-CT Data suggests BAT activation correlates with decreased triglycerides in BAT tissue More glucose was taken up (on average) in skeletal muscle & BAT tissue post-cold adaptation Uncoupling potein-1 (UCP-1) expressing white adipose tissue

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Is a Vegan Ketogenic diet Possible ?

Your friend the vegan Picture this. Your friend the vegan who’s always up on the latest plant-based superfood suddenly mentions wanting to try this thing called a ketogenic diet – more specifically, a vegan ketogenic diet. You’re told a ketogenic diet is super high in fat and very low in carbs. Because you’re a good friend, you think about what they’re saying, only to realize that vegan diets aren’t particularly fatty. Plants tend to store a lot of starch or

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Episode 13 – What happens to fructose-fed monkeys?

Short summary: In episode 13 Gabor and I review a 2011 study looking at the metabolic consequences of rhesus monkeys being fed a grain-based diet supplemented with 500mL of fructose loaded Kool-Aid a day over a year. Show notes: The study: Fructose-Fed Rhesus Monkeys: A Nonhuman Primate Model of Insulin Resistance, Metabolic Syndrome, and Type 2 Diabetes (Bremer et al. 2001) Gabor explains what is fructose, glucose and high-fructose corn syrup (HFCS) Gabor explains the enzymatic means by which HFCS

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Treatment for Metabolic Syndrome

treatment for metabolic syndrome

What is the metabolic syndrome? Metabolic syndrome is a set of criteria used to identify a pathological state of metabolism. If you qualify as having metabolic syndrome, this means one or more aspects of your metabolism is out of whack such that your odds of suffering from heart disease, stroke, diabetes, obesity, cancer etc. are substantially increased. Metabolic syndrome is identified by measuring five markers: waist circumference (WC), HDL cholesterol (HDLc), triglycerides (TG),  fasting plasma glucose (FPG) and both systolic

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