Blog Posts

Heart disease and cholesterol: a new hope

Heart disease and cholesterol- a new hope

Heart disease: the car, the driver & the crash Complex disease processes are best explained with analogies. Heart disease is no exception. To explain two competing theories of heart disease I’ll use an analogy consisting of a driver, a car and a crash. The anatomy of the heart and its more extended vascular system is the car. Some people have better genetics giving them stronger, more disease-proof hearts, just like some cars are more crash resistant. The driver of the

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A brief history of micronutrients

Nutrients: how much, how often, which ones? Most people can’t go more than a few minutes without air, about 3 days without water, approximately 9 to 11 days without sleep [1] and anywhere from weeks to over a year without food if they’re fat enough to start with [2] – but how long can you go without essential nutrients (vitamins, minerals, amino acids and fatty acids)? And how much do you need of each to be healthy? We’re still far

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Episode 19 – Marty Kendall on nutrient dense diets

Show notes: Marty Kendall launched https://optimisingnutrition.com/ in 2015 and has 2 excellent Facebook groups called Optimising Nutrition and Marty Kendall’s Nutrient Optimiser Marty explains how his engineering background helps him make sense of nutrition science What’s the nutrient optimizer? Marty explains his 3-pronged approach for recommending foods based on their insulin index, nutrient density and energy density We discuss the fact that RDIs (recommended daily intake of nutrients) were established in omnivorous diets (relatively) high in carbohydrates and how this

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Episode 18 – Peter Ballerstedt PhD: better nutrition through sustainable agriculture

Show notes: Peter gives his academic and professional background. Peter explains how his study of forage agronomy dove-tailed into his interest in nutrition after being faced with a diagnosis of diabetes. Peter defines ruminants. Peter explains how ruminants can reverse desertification, rendering land productive that otherwise cannot grow crops. Peter discusses the ratio of omega-6-to-omega-3 fats in our foods and how different food for cows affect the ratio in their meat Peter explains how absolute quantities of these fats might

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Episode 17 – Dr.Shawn Baker lifts like a crane and eats like a lion

Show notes: Amy Berger’s question “do you think the types of food we consume (and possibly even the amount) affect our nutrient requirements?” Comment 1: ”it seems like our requirements would be determined at least in part by the metabolic processes we have going on, and an all-meat diet might depend on particular processes more or less than an omnivorous low-carb diet, or a vegan diet, high-carb, or any other approach” Comment 2: “it seems like whatever was taken into

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Does beta hydroxybutyrate have an evil twin?

beta hydroxybutyrate

The discovery of CH3CH(OH)CH2CO2H CH3CH(OH)CH2CO2H = beta hydroxybutyrate. It’s a molecule your body makes from fats. The correct spelling is β-hydroxybutyrate or 3-hydroxybutyrate and is often abbreviated BHB. We’ll use beta hydroxybutyrate here. It all started in 1887. Well, actually 22 years earlier in 1865 when scientists discovered a molecule called acetoacetate in the pee of diabetic patients. Acetoacetate is a ketone or also known as a ketone body. Discovering acetoacetate eventually led them to discover beta hydroxybutyrate. Beta hydroxybutyrate was

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Episode 16 – The curious case of Dr. Ted Naiman

[warning: choppy audio in certain sections, my apologies ] In this episode I ask Dr.Ted Naiman the following questions:   How should doctors post patient results online and how not to do so? What’s the biggest misconception doctors have regarding diabetes? What’s the biggest misconception patients have regarding fat-loss? Dr.Naiman makes wonderful memes to explain concepts about health and nutrition. What’s a Protein-Sparing Modified Fast (PSMF)? Dr.Eric Westman places a lot of emphasis on carbohydrate restriction and very little on

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Can people with epilepsy benefit from the ketogenic diet?

What is the ketogenic diet? Some might consider the ketogenic diet to be a fad diet, however, it was discovered centuries ago for the dietary management of refractory epilepsy. The ketogenic diet is a high fat, adequate protein and low carbohydrate diet.   The diet was discovered by the observation of decreased seizure frequency during episodes of fasting.  In 1921, Dr. Wilder at Mayo clinic suggested the ketogenic diet for the long-term management of epilepsy. In terms of this suggestion, it

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Episode 15 – how do mTORC2 and ChREBP-β keep the fat cycle going?

Show notes: Study 1: “Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism” (2013 Tang et al.) This study looked at the activity of mTORC2 in the adipose tissue of miceFloxed-KO mice missing Rictor, a key element in the mTORC2 complex, were used in this study In the liver, de novo lipogenesis (DNL) correlates with insulin resistance (IR) but in white adipose tissue (WAT) it correlated with insulin sensitivity (IS) The activity of Carbohydrate-response Element Binding Protein

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Cold thermogenesis: how to freeze your fat off

Cold_thermogenesis_how_to_freeze_your_fat_off

Technology as a crutch The industrial age started in the late 18th century in the United Kingdom and with it, brought about technologies that now keep us in the Goldilocks zone, not too hot not too cold. In effect, we outsourced a fundamental aspect of what it means to stay alive and well temperature control Specifically, we now do very little cold thermogenesis. It’s a process mammals like us use to produce heat in order to stay warm. Our bodies

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