Episode 23 – Tucker Goodrich dishes on bad fats

Show notes:

Tucker’s blog is http://yelling-stop.blogspot.com and his Twitter is @tuckergoodrich

  • Could avoiding seed oils be why Tucker, I and others have noticed the same anecdotal experience of increased resistance to sunburn?
  • We discuss the apportioning of seed oils, refined flours and sugars to diseases of civilization
    • (2004) Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA
      • “In summary, chronic caloric excess of n-6 PUFA when coupled with acute diabetes of only 4 days precipitated mitochondrial abnormalities, a steep drop in GSH, altered substrate utilization, and myocardial TG deposition. Given that these hearts also demonstrated necrosis and extensive myocardial cell loss, a feature that is predominant only in chronic diabetes (1, 14, 16, 24), our data suggest that this mode of cell death in PUFA-fed diabetic hearts is an important factor in accelerating diabetic cardiomyopathy
      • “Overall, our data suggest that the type, rather than the amount, of fatty acid controls lipotoxic apoptosis”
    • (2017) Petro Dobromylskyj Musing about linoleic acid
      • “Anyone who has read Weston Price or Vilhjalmur Stefansson will be only too aware that the substances most easily transported over long distances to affect unacculturated peoples were sugar and flour. No one was carting margarine or corn oil to the Arctic in the early part of the last century. Both fructose and alcohol, both of which deliver largely uncontrolled calories into cells, can clearly generate aspects of metabolic syndrome”
      • Tucker raises the point that, just like many olive oils nowadays are adulterated with canola oil, the food brought to the Arctic could also have been adulterated with seed oils
  • We discuss Japanese and Okinawan epidemiology
    • (1992) Nutrition for the Japanese elderly
      • “Eating meat was not stigmatised, and consumption of pork and goat was historically high. It was exceptional among Japanese food consumption”
      • “ [Okinawa vs Japan average] The intake of meat was higher in Okinawa […] On the other hand, the intake of fish was lower in Okinawa […] Intake of NaCl was lower […] Deep colored vegetables were taken more in Okinawa“
      • “unexpectedly, we did not find any vegetarians amongst the centenarians
    • (2001) History and characteristics of Okinawan longevity food
      • Pigs were first brought into the Ryukyus by Chinese immigrants in 1392, but they failed to become widespread because of a lack of food in the farms of the time. When sweet potatoes were introduced from Fukkien Province in China, however, the practice of pig-breeding spread rapidly, marking the beginning of the meat eating culture
  • We discuss some mechanisms behind how seed oils exert their negative effects, in particular through their modification to oxidized linoleic acid metabolites (OxLAMs)
    • OxLAMs affect mitochondrial structure and thus function (e.g. modifying cardiolipin)
    • HNE is a particularly harmful product of omega-6 oxidation, being cytotoxic and genotoxic
  • (2017) Petro Dobromylskyj On drinking varnish (varnish refers to linoleic acid [LA])
    • “When PUFA are being oxidised in the mitochondria of adipocytes, those adipocytes are unable to resist the signal from insulin to distend with fat. The more double bonds in the PUFA has, the greater the effect. Linseed oil should be used for making varnish”

There’s so much more to discuss with Tucker so we promised a round 2 very soon!

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