Episode 3 – Affecting fat loss in rodents by caloric restriction, knocking out insulin genes and seeing how incretin hormones play into it

In Episode 3 of the Break Nutrition show we discussed rodent studies showing an insulin gene dosage-dependent effect on adiposity, the interplay between caloric restriction & circulating insulin, as well as how incretin hormones affect fat loss dynamics.

Caloric Restriction Paradoxically Increases Adiposity in Mice With Genetically Reduced Insulin.

Link: https://www.ncbi.nlm.nih.gov/m/pubmed/27145011/

Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity.

Link: https://www.ncbi.nlm.nih.gov/m/pubmed/26155745/?i=3&from=/27145011/related

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