Episode 1 – Linking dysregulated adipocyte fat flow to diabetes

In Episode 1 of the BreakNutrition Show we talked about how how dysregulated fat flow from fat cells can drive the creation of new glucose in the liver and lead to diabetes, here is the paper:

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

link: https://www.ncbi.nlm.nih.gov/pubmed/25662011

1 comments On Episode 1 – Linking dysregulated adipocyte fat flow to diabetes

  • I am disappointed no one answered you, Holly. I also would like some actionable conclusion geared for the layperson. I am brand new to this podcast and will be working my way through. I am familiar with Gabor and respect his work greatly. In my humble layperson’s opinion…I do not believe they are talking about the fat you eat??? but a disrupted signal (caused by inflammation in Adipose tissue) which stimulates an inappropriate amount of fat (and at inappropriate times) to be released from Adipose tissue which then triggers gluconeogenesis in the liver. I will have to listen multiple times and see if I can understand more and correctly. I would like to understand what causes the inflammation and disruption??? Also…sounds like it would create a circular response…what would happen to the excess glucose which is created? I am going back once again before I loose what I think I understood. Wish me luck. 🙂

    Thank you Raphael and Gabor – you are legions ahead of me but I like the challenge. 🙂

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