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Episode 27 – Adipocytes and insulin resistance

Show notes: 60% of US adults are overweight to moderately obese but within that group there is great heterogeneity in their response to insulin ⇒ their degree of insulin sensitivity can vary more than sixfold at any given BMI within this range Adults constantly form and replace adipose cells, called turnover 2 places to measure fat are the femoral (leg fat) and subcutaneous (under your skin and predominantly white) adipose tissues For IMGU (insulin mediated glucose uptake), the higher the

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Episode 26 – Dr.Bikman: well behaved fat and good insulin signaling FTW

Discuss further on: https://ask.breaknutrition.com Show notes: Here’s Dr.Bikman’s Twitter profile The Bikman lab is in The College of Life Sciences of Brigham Young University It focuses on identifying first “the molecular mechanisms that explain the increased risk of disease that accompanies weight gain, with particular emphasis on the etiology of insulin resistance and disrupted mitochondrial function. Second, we hope to reveal novel cellular processes that are responsible for fat development” Dr.Bikman enumerates some of the metabolic drugs used in disease

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Episode 25 – Larry & Kay Lynne Diamond: education is power

Show notes: Larry started LCHF May 2013 lost 45kg (100lbs) Larry’s fat-loss and health journey on www.dietdoctor.com He’s @natureboyrr on Twitter Kay Lynne started LCHF lost 32kg (70lbs) Kay Lynne’s fat-loss and health journey on www.marksdailyapple.com I ask Larry and Kay Lynne about how to best teach kids about food and health Kay Lynne explains the social challenge inherent for her daughter given she eats healthily (meat, vegetables, tubers and fruit) instead of the junk-food her classmates eat, but that

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Episode 24 – Tucker and Gabor on Seed Oils vs Refined Carbs – Part 2

Show notes: You can find Tucker Goodrich at http://yelling-stop.blogspot.com and on Twitter @tuckergoodrich Oxidative stress is the inevitable result of metabolism and basic chemistry, resulting from reactive oxygen species (ROS) like “slow” reacting hydrogen peroxide and “fast” reacting peroxyl radicals. Omega-6 and omega-3 PUFAs form peroxidation products like malondialdehyde, 4-hydroxynonenal (HNE) , isoprostanes or 9- and 13-hydroxyoctadecadienoic acids. Here’s a study from 2015 for more on PUFA chemistry.  PUFAs are not stable at the physiological temperature of ~37°C. When anti-oxidant action is lacking

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Why controlling gluconeogenesis is important for reversing diabetes?

Introduction: our very own sugar factory Step into the low-carb world and soon enough you’ll hear the term GlucoNeoGenesis. GNG for short, is your body’s ability to construct glucose, a kind of sugar, out of molecules that aren’t glucose. It does this to ensure that, if you don’t eat any carbs, the cells in your body that need glucose will still get enough of it. It’s one reason why humans are so good at fasting or delaying death from starvation

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Episode 23 – Tucker Goodrich dishes on bad fats

Show notes: Tucker’s blog is http://yelling-stop.blogspot.com and his Twitter is @tuckergoodrich Could avoiding seed oils be why Tucker, I and others have noticed the same anecdotal experience of increased resistance to sunburn? We discuss the apportioning of seed oils, refined flours and sugars to diseases of civilization (2004) Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA “In summary, chronic caloric excess of n-6 PUFA when coupled with acute diabetes of only 4 days precipitated mitochondrial

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Episode 22 – Dietary (in)sanity with Dr.Ede

Show notes: Dr.Ede’s interesting professional background includes working as lab assistant in places like the Joslin Diabetes Center and the SUNY Stony Brook Department of Dermatology. She also became an M.D. at the University of Vermont College of Medicine and completed her residency in adult psychiatry at Harvard. In 2012 she completed a graduate course in nutrition from the Harvard School of Public Health entitled “The Science of Human Nutrition”. She is now the psychiatrist for Smith College (Northampton, Massachusetts)

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Omega-6 fats: the alternative hypothesis for diseases of civilization

Written by Tucker Goodrich Find him at http://yelling-stop.blogspot.com and @tuckergoodrich on Twitter Diseases of civilization The world is facing a health crisis of unprecedented proportions. What have become known as chronic diseases, Western Diseases, or Diseases of Civilization (DC), have become pandemic as populations around the world adopt the lifestyle that first became prevalent in the country that perfected industrialization, the United States. What are they? The DCs revolve around the Metabolic Syndrome (MetSyn), a set of signs of disease that include central

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Episode 21 – measuring Acetyl-CoA in a live rat, for the sake of metabolism

Show notes: A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo (Perry and Shulman et al. 2017) Background Futile fat cycling “Regulation is easier if competing reactions are maintained in a cycling steady-state and then biased in one or another direction. This becomes, in the end, more efficient  than starts and stops in response to different conditions” Acetyl-CoA contributes to GNG, glucose oxidation, protein acetylation and the synthesis of steroids as well as fatty acids Episode 1 Break Nutrition study

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Episode 20 – Sweet, sweet insulin and you

Show notes: Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion (Kyriazis et al. 2012) Background Beta-cell metabolized nutrients (e.g. amino acids & glucose) stimulate insulin secretion whilst GLP-1 interacts with the beta-cell’s cell-surface GPCRs to stimulate insulin secretion [G-protein coupled receptor] There are many more Non-metabolizable insulin secretagogues than Metabolizable ones TRPM5 (Transient receptor potential cation channel subfamily M member 5) is found on surface of beta-cells, transducing taste for bitter, sweet, umami &

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