Blog Posts

Episode 24 – Tucker and Gabor on Seed Oils vs Refined Carbs – Part 2

Show notes: You can find Tucker Goodrich at http://yelling-stop.blogspot.com and on Twitter @tuckergoodrich Oxidative stress is the inevitable result of metabolism and basic chemistry, resulting from reactive oxygen species (ROS) like “slow” reacting hydrogen peroxide and “fast” reacting peroxyl radicals. Omega-6 and omega-3 PUFAs form peroxidation products like malondialdehyde, 4-hydroxynonenal (HNE) , isoprostanes or 9- and 13-hydroxyoctadecadienoic acids. Here’s a study from 2015 for more on PUFA chemistry.  PUFAs are not stable at the physiological temperature of ~37°C. When anti-oxidant action is lacking

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Gluconeogenesis

Introduction: our very own sugar factory Step into the low-carb world and soon enough you’ll hear the term GlucoNeoGenesis. GNG for short, is your body’s ability to construct glucose, a kind of sugar, out of molecules that aren’t glucose. It does this to ensure that, if you don’t eat any carbs, the cells in your body that need glucose will still get enough of it. It’s one reason why humans are so good at fasting or delaying death from starvation

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Episode 23 – Tucker Goodrich dishes on bad fats

Show notes: Tucker’s blog is http://yelling-stop.blogspot.com and his Twitter is @tuckergoodrich Could avoiding seed oils be why Tucker, I and others have noticed the same anecdotal experience of increased resistance to sunburn? We discuss the apportioning of seed oils, refined flours and sugars to diseases of civilization (2004) Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA “In summary, chronic caloric excess of n-6 PUFA when coupled with acute diabetes of only 4 days precipitated mitochondrial

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Episode 22 – Dietary (in)sanity with Dr.Ede

Show notes: Dr.Ede’s interesting professional background includes working as lab assistant in places like the Joslin Diabetes Center and the SUNY Stony Brook Department of Dermatology. She also became an M.D. at the University of Vermont College of Medicine and completed her residency in adult psychiatry at Harvard. In 2012 she completed a graduate course in nutrition from the Harvard School of Public Health entitled “The Science of Human Nutrition”. She is now the psychiatrist for Smith College (Northampton, Massachusetts)

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Omega-6 fats: the alternative hypothesis for diseases of civilization

Written by Tucker Goodrich Find him at http://yelling-stop.blogspot.com and @tuckergoodrich on Twitter Diseases of civilization The world is facing a health crisis of unprecedented proportions. What have become known as chronic diseases, Western Diseases, or Diseases of Civilization (DC), have become pandemic as populations around the world adopt the lifestyle that first became prevalent in the country that perfected industrialization, the United States. What are they? The DCs revolve around the Metabolic Syndrome (MetSyn), a set of signs of disease that include central

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Episode 21 – measuring Acetyl-CoA in a live rat, for the sake of metabolism

Show notes: A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo (Perry and Shulman et al. 2017) Background Futile fat cycling “Regulation is easier if competing reactions are maintained in a cycling steady-state and then biased in one or another direction. This becomes, in the end, more efficient  than starts and stops in response to different conditions” Acetyl-CoA contributes to GNG, glucose oxidation, protein acetylation and the synthesis of steroids as well as fatty acids Episode 1 Break Nutrition study

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Episode 20 – Sweet, sweet insulin and you

Show notes: Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion (Kyriazis et al. 2012) Background Beta-cell metabolized nutrients (e.g. amino acids & glucose) stimulate insulin secretion whilst GLP-1 interacts with the beta-cell’s cell-surface GPCRs to stimulate insulin secretion [G-protein coupled receptor] There are many more Non-metabolizable insulin secretagogues than Metabolizable ones TRPM5 (Transient receptor potential cation channel subfamily M member 5) is found on surface of beta-cells, transducing taste for bitter, sweet, umami &

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Study review: Dietary sugars, not lipids, drive hypothalamic inflammation

Study background Today’s post briefly reviews a neat little study in mice from 2017 by Gao et al. [1]. It’s called “Dietary sugars, not lipids, drive hypothalamic inflammation”. Isn’t it nice to a have a clear study title giving away the ending? More and more scientific papers now have a graphical and text abstract, as does this paper. This graphical abstract illustrates how, in mice, dietary fat and carbohydrate individually and synergistically contribute to the production of advanced-glycation end-products (AGEs).

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Reversing brain damage & cancer: 2 case-reports

Two interesting medical case-reports caught my eye last week. I want to tell you about them because they’re different avenues to appreciating the importance of metabolism in health and disease, something I already emphasize when discussing diet. Reversing brain damage with oxygen therapy The first case-report is about reversing brain damage in a 2-year old girl in America [1]. However interesting these sort of medical firsts are, we should remember not to overgeneralize these encouraging results because we’re dealing with

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Heart disease and cholesterol: a new hope

Heart disease and cholesterol- a new hope

Heart disease: the car, the driver & the crash Complex disease processes are best explained with analogies. Heart disease is no exception. To explain two competing theories of heart disease I’ll use an analogy consisting of a driver, a car and a crash. The anatomy of the heart and its more extended vascular system is the car. Some people have better genetics giving them stronger, more disease-proof hearts, just like some cars are more crash resistant. The driver of the

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